全文获取类型
收费全文 | 34910篇 |
免费 | 2932篇 |
国内免费 | 1125篇 |
专业分类
耳鼻咽喉 | 290篇 |
儿科学 | 245篇 |
妇产科学 | 1868篇 |
基础医学 | 6536篇 |
口腔科学 | 692篇 |
临床医学 | 3309篇 |
内科学 | 3863篇 |
皮肤病学 | 226篇 |
神经病学 | 3475篇 |
特种医学 | 1809篇 |
外国民族医学 | 1篇 |
外科学 | 4047篇 |
综合类 | 4600篇 |
现状与发展 | 6篇 |
预防医学 | 1595篇 |
眼科学 | 605篇 |
药学 | 3682篇 |
11篇 | |
中国医学 | 1171篇 |
肿瘤学 | 936篇 |
出版年
2023年 | 434篇 |
2022年 | 682篇 |
2021年 | 1124篇 |
2020年 | 1087篇 |
2019年 | 999篇 |
2018年 | 1060篇 |
2017年 | 1023篇 |
2016年 | 1025篇 |
2015年 | 1101篇 |
2014年 | 2011篇 |
2013年 | 2161篇 |
2012年 | 1872篇 |
2011年 | 2099篇 |
2010年 | 1711篇 |
2009年 | 1631篇 |
2008年 | 1584篇 |
2007年 | 1636篇 |
2006年 | 1535篇 |
2005年 | 1337篇 |
2004年 | 1255篇 |
2003年 | 1185篇 |
2002年 | 990篇 |
2001年 | 842篇 |
2000年 | 723篇 |
1999年 | 618篇 |
1998年 | 602篇 |
1997年 | 612篇 |
1996年 | 512篇 |
1995年 | 529篇 |
1994年 | 482篇 |
1993年 | 436篇 |
1992年 | 416篇 |
1991年 | 404篇 |
1990年 | 338篇 |
1989年 | 309篇 |
1988年 | 277篇 |
1987年 | 245篇 |
1986年 | 195篇 |
1985年 | 272篇 |
1984年 | 236篇 |
1983年 | 142篇 |
1982年 | 218篇 |
1981年 | 199篇 |
1980年 | 158篇 |
1979年 | 137篇 |
1978年 | 128篇 |
1977年 | 113篇 |
1976年 | 105篇 |
1975年 | 43篇 |
1974年 | 39篇 |
排序方式: 共有10000条查询结果,搜索用时 328 毫秒
81.
《Journal of Science and Medicine in Sport》2020,23(6):536-540
ObjectivesMuscle damage symptoms induced by unaccustomed eccentric contraction exercise can be reduced by repeating the experience several times. This phenomenon is termed the repeated bout effect. Although traditional biochemical markers require invasive blood sampling, biochemical measurements have recently been developed that can be non-invasively performed using urinary titin N-terminal fragment (UTF). However, it is unclear whether UTF can reflect the repeated bout effect. Therefore, the aim of the present study was to clarify whether UTF decreased with the repeated bout effect.DesignThis study compared changes in muscle damage markers between bouts of exercise performed for the first and second time.MethodsEight young men performed 30 eccentric exercises of the elbow flexor on the first day of the first week (Bout 1). A second bout of eccentric exercises, same as the first, was performed 2 weeks later, (Bout 2). The dependent variables were muscle soreness (SOR), maximal voluntary isometric contraction (MVIC), range of motion (ROM), creatine kinase (CK), and UTF. All dependent variables were analyzed using two-way analysis of variance.ResultsNo significant difference was observed in workload or peak torque between the first and second exercise bouts. SOR as well as CK and UTF were significantly lower and ROM and MVIC were significantly higher in Bout 2 in comparison to Bout 1.ConclusionsThese results suggest that UTF sensitively reflects the repeated bout effect and exercise-induced muscle damage can be non-invasively measured. 相似文献
82.
ABSTRACT The purpose of this study is to analyse the effects of KT on trunk strength with respect to different angular speeds when applied to the trunks of healthy women. Forty healthy female participants were randomly distributed into two groups: the placebo group (PG) in which placebo KT was applied and the experimental group (EG). Participants’ trunk concentric flexion and extension muscle strength were measured using an isokinetic dynamometer in two different angular speeds (60°/s ? 180°/s). In both PG and EG groups, there was no significant difference measured immediately after taping at the two angular speed values. In the measurements taken 48 h later, as regards PG trunk flexion, extension muscle strength increased significantly (p = 0.0001) at 60°/sc. angular speed while, for the EG only, the strength of trunk extension muscle increased significantly (p = 0.002). It was observed, that to ensure an increase in strength, waiting for a certain length of time was required. Lower angular speeds and short-term applied KT improved the strength of the trunk extension muscle. 相似文献
83.
84.
Lisa Lighthall Haubert Sara J. Mulroy Philip S. Requejo Somboon Maneekobkunwong JoAnne K. Gronley Jeffery W. Rankin 《The journal of spinal cord medicine》2020,43(5):594-606
Objective: Shoulder pain after spinal cord injury (SCI) is attributed to increased mobility demands on the arms and negatively impacts independence and quality of life. Repetitive superior and posterior shoulder joint forces produced during traditional wheelchair (WC) locomotion can result in subacromial impingement if unopposed, as with muscular fatigue or weakness. ROWHEELS® (RW), geared rear wheels that produce forward WC movement with backward rim pulling, could alter these forces. Design: Cross sectional. Setting: Research laboratory at a rehabilitation hospital. Participants: Ten manual WC users with paraplegia. Outcome measures: Propulsion characteristics and right upper extremity/trunk kinematics and shoulder muscle activity were collected during ergometer propulsion: (1) self-selected free speed reverse propulsion with RW, (2) matched-speed reverse (rSW), and (3) forward propulsion (fSW) with instrumented Smartwheels (SW). Inverse dynamics using right-side SW rim kinetics and kinematics compared shoulder kinetics during rSW and fSW. Results: Free propulsion velocity, cycle distance and cadence were similar during RW, rSW and fSW. Overall shoulder motion was similar except that peak shoulder extension was significantly reduced in both RW and rSW versus fSW. Anteriorly and inferiorly directed SW rim forces were decreased during rSW versus fSW propulsion, but posteriorly and superiorly directed rim forces were significantly greater. Superior and posterior shoulder joint forces and flexor, adductor, and external rotation moments were significantly less during rSW, without a significant difference in net shoulder forces and moments. Traditional propulsive-phase muscle activity was significantly reduced and recovery-phase muscle activity was increased during reverse propulsion. Conclusion: These results suggest that reverse propulsion may redirect shoulder demands and prevent subacromial impingement, thereby preventing injury and preserving independent mobility for individuals with paraplegia. 相似文献
85.
Valentine Zimermann Vargas Caroline Motta Beatriz Peres Rodrigo Luiz Vancini Claudio Andre Barbosa De Lira 《The Physician and sportsmedicine》2020,48(1):105-109
ABSTRACTBackground: As a consequence of years of soccer training and sexual maturation, there is an increase in lower body muscle mass and strength especially in the knee extensors and flexors muscles. In this context, the lack of knee joint stability, resulting from strength imbalance between knee extensor and flexors muscles, has been associated with knee injuries. The aim of this study was to compare the knee flexor and extensor muscle peak torque, average power, contralateral deficit, conventional and functional balance ratios of female soccer players from different age groups.Methods: Sixty-six female soccer players were divided into four groups: under 13 (U13), under 15 (U15), under 17 (U17) years old and professional (PRO). Flexor and extensor knee muscle strength in concentric and eccentric actions of both limbs were assessed using isokinetic dynamometer.Results: For the dominant limb, the knee concentric extensor muscles peak torques, assessed at 60 and at 240 deg/sec, and the average power of U15 group were significantly higher than U13 group. Extensor muscle average power of the PRO group was higher than U17. Dominant knee flexor average power of U15 was significantly higher than the U13 group. Peak torque at 60 deg/sec and 240 deg/sec and average power of the PRO group were higher than the U17 group. No differences were found regarding the eccentric action for flexor and extensor muscles. Conventional and functional balance ratios were similar among all age group, except for U13, which presented higher values than the U15 group for the dominant limb.Conclusions: The greatest improvement in muscular performance occur when the athlete starts practicing soccer (after U13) and when they become professional (after U17) and the balance ratios, and muscle balance ratios remain stable in all age groups, although they are below the recommended level in the literature, which may increase the risk for lower limb injury. 相似文献
86.
Abstract During pulmonary rehabilitation, a subset of subjects with COPD requires adjunct therapy to achieve high-intensity training. Both noninvasive ventilation (NIV) and inspiratory muscle training (IMT) are available to assist these subjects. We aimed to prime the respiratory muscles before NIV with IMT, anticipating additive effects for maximal exercise tolerance (T lim) and dyspnea/leg fatigue relief throughout the exercise as primary outcomes. Changes in the respiratory pattern were secondary outcomes. COPD subjects performed a total of four identical constant work rate tests on a cycle ergometer at 75% of maximum work rate, under control ventilation (SHAM, 4?cm H2O) or proportional assisted ventilation (PAV, individually adjusted), before and after 10 sessions of high-intensity IMT (three times/week) during 30?days. Two-way RM ANOVA with appropriate corrections were performed. Final analysis in nine subjects showed improved T lim (Δ = 111?s) and lower minute-ventilation (Δ = 4?L.min?1) at exhaustion, when comparing the IMT effects within the PAV modality (p?=?0.001 and p?=?0.036, respectively) and improved T lim for PAV vs. SHAM (PAV main-effect, p?=?0.001; IMT main-effect, p?=?0.006; PAV vs. IMT interaction, p?=?0.034). In addition, IMT?+?PAV association, compared to PAV alone, resulted in lower respiratory frequency (IMT main-effect, p?=?0.009; time main-effect, p?<?0.0001; IMT vs. time interaction, p?=?0.242) and lower inspiratory time related to duty cycle (IMT main-effect, p?=?0.018; time main-effect, p?=?0.0001; IMT vs. time interaction, p?=?0.004) throughout exercise. The addition of IMT prior to a PAV-supported aerobic bout potentiates exercise tolerance and dyspnea relief and induces favourable changes in ventilatory pattern in severe COPD during high-intensity training (Brazilian Registry of Clinical Trials, number RBR-6n3dzz). 相似文献
87.
《Journal of the American Medical Directors Association》2020,21(3):300-307.e2
Clinical and research interest in sarcopenia has burgeoned internationally, Asia included. The Asian Working Group for Sarcopenia (AWGS) 2014 consensus defined sarcopenia as “age-related loss of muscle mass, plus low muscle strength, and/or low physical performance” and specified cutoffs for each diagnostic component; research in Asia consequently flourished, prompting this update. AWGS 2019 retains the previous definition of sarcopenia but revises the diagnostic algorithm, protocols, and some criteria: low muscle strength is defined as handgrip strength <28 kg for men and <18 kg for women; criteria for low physical performance are 6-m walk <1.0 m/s, Short Physical Performance Battery score ≤9, or 5-time chair stand test ≥12 seconds. AWGS 2019 retains the original cutoffs for height-adjusted muscle mass: dual-energy X-ray absorptiometry, <7.0 kg/m2 in men and <5.4 kg/m2 in women; and bioimpedance, <7.0 kg/m2 in men and <5.7 kg/m2 in women. In addition, the AWGS 2019 update proposes separate algorithms for community vs hospital settings, which both begin by screening either calf circumference (<34 cm in men, <33 cm in women), SARC-F (≥4), or SARC-CalF (≥11), to facilitate earlier identification of people at risk for sarcopenia. Although skeletal muscle strength and mass are both still considered fundamental to a definitive clinical diagnosis, AWGS 2019 also introduces “possible sarcopenia,” defined by either low muscle strength or low physical performance only, specifically for use in primary health care or community-based health promotion, to enable earlier lifestyle interventions. Although defining sarcopenia by body mass index–adjusted muscle mass instead of height-adjusted muscle mass may predict adverse outcomes better, more evidence is needed before changing current recommendations. Lifestyle interventions, especially exercise and nutritional supplementation, prevail as mainstays of treatment. Further research is needed to investigate potential long-term benefits of lifestyle interventions, nutritional supplements, or pharmacotherapy for sarcopenia in Asians. 相似文献
88.
Measuring conduction velocity distributions in peripheral nerves using neurophysiological techniques
《Clinical neurophysiology》2020,131(7):1581-1588
ObjectiveTo determine how long it takes for neural impulses to travel along peripheral nerve fibers in living humans.MethodsA collision test was performed to measure the conduction velocity distribution of the ulnar nerve. Two stimuli at the distal and proximal sites were used to produce the collision. Compound muscle or nerve action potentials were recorded to perform the measurements on the motor or mixed nerve, respectively. Interstimulus interval was set at 1–5 ms. A quadri-pulse technique was used to measure the refractory period and calibrate the conduction time.ResultsCompound muscle action potential produced by the proximal stimulation started to emerge at the interstimulus interval of about 1.5 ms and increased with the increment in interstimulus interval. Two groups of motor nerve fibers with different conduction velocities were identified. The mixed nerve showed a wider conduction velocity distribution with identification of more subgroups of nerve fibers than the motor nerve.ConclusionsThe conduction velocity distributions in high resolution on a peripheral motor and mixed nerve are different and this can be measured with the collision test.SignificanceWe provided ground truth data to verify the neuroimaging pipelines for the measurements of latency connectome in the peripheral nervous system. 相似文献
89.
Jean-Philippe Leduc-Gaudet Martin Picard Félix St-Jean Pelletier Nicolas Sgarioto Marie-Jo?lle Auger Joanne Vallée Richard Robitaille David H. St-Pierre Gilles Gouspillou 《Oncotarget》2015,6(20):17923-17937
Skeletal muscle aging is associated with a progressive decline in muscle mass and strength, a process termed sarcopenia. Evidence suggests that accumulation of mitochondrial dysfunction plays a causal role in sarcopenia, which could be triggered by impaired mitophagy. Mitochondrial function, mitophagy and mitochondrial morphology are interconnected aspects of mitochondrial biology, and may coordinately be altered with aging. However, mitochondrial morphology has remained challenging to characterize in muscle, and whether sarcopenia is associated with abnormal mitochondrial morphology remains unknown. Therefore, we assessed the morphology of SubSarcolemmal (SS) and InterMyoFibrillar (IMF) mitochondria in skeletal muscle of young (8-12wk-old) and old (88-96wk-old) mice using a quantitative 2-dimensional transmission electron microscopy approach. We show that sarcopenia is associated with larger and less circular SS mitochondria. Likewise, aged IMF mitochondria were longer and more branched, suggesting increased fusion and/or decreased fission. Accordingly, although no difference in the content of proteins regulating mitochondrial dynamics (Mfn1, Mfn2, Opa1 and Drp1) was observed, a mitochondrial fusion index (Mfn2-to-Drp1 ratio) was significantly increased in aged muscles. Our results reveal that sarcopenia is associated with complex changes in mitochondrial morphology that could interfere with mitochondrial function and mitophagy, and thus contribute to aging-related accumulation of mitochondrial dysfunction and sarcopenia. 相似文献
90.
对易筋经与核心稳定性训练的锻炼方式及作用效果的研究进行比较分析。从两者的训练状态及对形体、呼吸、意识的调节方式入手,并结合其在增强肌力、提高平衡力、预防运动损伤方面所起的共同疗效进行深入思考,探讨易筋经锻炼可能对人体核心稳定性的影响,为进一步研究易筋经的作用机制提供理论依据。 相似文献